ABSTRACT
Statement of Problem: Basal cell carcinoma [BCC], the most common skin cancer, is a locally invasive malignant epidermal tumor with ulceration and destruction of underlying structures
Purpose: The purpose of this study was clinicopathological evaluation of BCC in the state and the private pathology centers in Hamadan province during 1990-2010
Materials and Method: In this retrospective study all histopathologically proven cases of BCC were reviewed and the related information including age, gender, place of residency and number of tumors for the patients alongside with the site of occurrence, size, histopathological and clinical type of the lesions were collected and then statistically analyzed, using SPSS software
Results: A total of 804 incidents of BCC were diagnosed in 746 patients [296 females and 450 males] with the most affected site being in the head-face [84.8%], neck [2.6%], trunk [1.6%] and limbs [0.9 %] and 10.1% cases with unknown site. The mean age for the patients was 61.77+/-13.75 years [63.07+/- 13.44 for males, 59.81 +/- 14.01 for females] and the highest frequency [27.2%] occurred among 60-69 years age group. Nodular type was the most common clinical and histopathological BCC lesions studied whereas the mean size of the lesions was 15.67 +/- 11.06 mm with more frequency rate in urban than rural regions
Conclusion: This study focuses on the survey of BCC in Hamadan province but regarding to insufficiency of the data collected by state and provincial pathology centers about the BCC cases reported; it is highly recommended to apply comprehensive questionnaire, which are designated by skillful professionals who are familiar with the lesion nationally
ABSTRACT
Severe or lethal damages of toxoplasmosis clearly indicate the need for the development of a more effective vaccine. Immunization with recombinant plasmid encoding protective proteins is a promising vaccination technique. Therefore, this study aimed to evaluate the immunization with plasmid encoding GRA5 antigen of Toxoplasma gondii in BALB/c mice. In this experimental study, three groups of BALB/c mice [n=10 in each group] were selected using simple random sampling. GRA5 gene was cloned into pcDNA3 plasmid and purified by plasmid purification kits and then the product was injected [IM]. To determine the status of cellular and hurnoral immunity, the 11-4, IFN- gamma and IgG; IgG2a, IgG subtypes were evaluated respectively using the ELISA-based assay. The group immunized with pcGRA5 indicated a significant augmented response in humoral and cellular immunity [P
ABSTRACT
To examine the effects of soy [in the form of textured soy protein [TSP] and soy-nut] on body composition in elderly women with metabolic syndrome [MetS]. A 12-week randomized clinical trial was conducted on 75 women between 60-70 years of age with MetS in rural health clinics around Babol, Iran in 2009. The participants were randomly assigned to one of the three groups of soy-nut [35g/d], TSP [35g/d] and control. Body fat, lean mass and anthropometric indicators were measured before and after intervention, too. Participants were classified as overweight and showing android fat distribution. After 12 weeks of intervention, both soy-nut and TSP groups showed an increase of non-significant in lean mass [0.9 and 0.7 kg], hip circumference [0.45 and 0.28 cm], triceps skinfold [TSF] thickness [0.87 and 0.67mm] and reduction in BMI [-0.15 and -0.33], waist circumference [-0.83 and -1.2] and body fat [-1.5% and -1.7%]. Significant increase in the mean change of TSF and lean mass was observed in the users of soy-nut compared to the control group [P<0.01, P<0.05]. 12-week intervention of soy had a mild favorable effect on body composition in elderly women with MetS
Subject(s)
Humans , Female , Body Composition , Metabolic Syndrome , Aged , Soybean Proteins , Adipose Tissue , AnthropometryABSTRACT
Metabolic syndrome, a collection of risk factors for cardiovascular risk factors, refers to a cluster of symptoms, the simultaneous occurrence of which in a person is more likely than the occurrence of each perse. The criteria proposed by the International Diabetes Federation for the diagnosis of this syndrome include central obesity, increased triglycerides, decreased HDL-C, hypertension, and increased fasting blood sugar. Signs of metabolic syndrome can be determined through the interconnected physical and chemical changes in the human body, genetic and environmental factors. One of the most effective factors in metabolic syndrome is change in the lipid profiles. Based on the roles of apolipoproteins in lipid metabolism, the possibility of their role in metabolic syndrome has been documented. The aim of this review is to evaluate the genetic roles of apolipoproteins in metabolic syndrome. Overall, the evidence suggests that the apolipoproteins A particularly APOA5 more associated with this syndrome. On the other hand, despite the prominent role of apolipoprotein B in fat metabolism, there is no evidence on any correlation between B-100 apolipoprotein and lipoproteins such as HDL and triglyceride levels of the symptoms of metabolic syndrome
ABSTRACT
To compare post-operative pain with cooling photorefractive keratectomy [PRK] versus conventional PRK. A prospective clinical trial was performed on 94 eyes from 47 patients scheduled for PRK. Patients were randomly assigned to either cooling or conventional PRK. Pain was evaluated 6, 12, 24 and 48 hours post-operation using a visual analogue scale [VAS]. Corneal haze, conjunctival and palpebral edema, and complications were also assessed. Mean age of the patients was 24.8 +/- 4.5 [range: 18-36 years] and mean refractive error was 3.6 +/- 1.6 diopters. Median pain score in the cooling group at 6 and 12 hours was 15 and 10, respectively and zero at 24 and 48 hours. Median pain score in the conventional group at 6 and 12 hours was 30 and 15 and was zero at 24 and 48 hours. There was no adverse effect in either of the groups. Cooling PRK effectively reduces post-operative pain after PRK without any additional adverse effect